Decoding Genetic Predisposition: Understanding BRCA Gene Mutations

Unraveling BRCA Gene Mutations and Breast Cancer Risk

BRCA gene mutations, specifically the BRCA1 and BRCA2 genes, are associated with a genetic predisposition to breast cancer. These genes normally play a crucial role in repairing damaged DNA. When mutations occur, their ability to repair DNA damage becomes compromised, which can lead to the unchecked growth of abnormal cells, ultimately increasing the likelihood of cancer development.

An estimated 45% to 72% of women who carry these harmful gene mutations will develop breast cancer in their lives, compared to about 13% of the general population. Although breast cancer in men is rare, men who carry the genes have an increased risk of 1% to 10%. Hereditary breast cancer typically presents earlier in life and is likely to develop contralaterally within 20 years if it develops in one breast first.

Several factors may influence the risk, including which mutation is inherited. BRCA1 presents a slightly higher risk of developing breast cancer compared to BRCA2, but both are uncommon, comprising only 5% to 10% of all breast cancer diagnoses. Carrying either mutation is not an absolute indicator that you will develop the disease. (more…)

When thinking about breast cancer, one doesn’t typically think of men being diagnosed with it.  Although it is not nearly as common as it is in women, it something that undoubtedly deserves awareness. February 4th is World Cancer Day, and our team of surgeons would like to shed light on breast cancer in men and what you should be aware of. Key Facts about Male Breast Cancer: About 1% of all breast cancer diagnoses are in men. There are around… Read More

Breastfeeding is one of the best ways a mother and her newborn can strengthen their emotional connection, while also providing her infant with essential nutrients for development. While not all mothers chose to breastfeed, the process of nursing is a topic that brings on a lot of questions to new mothers, especially those who are breast cancer survivors. The ability to breastfeed depends on a number of factors, including milk production, the milk ducts, and the nipple/areola.   Chemotherapy and other Long-term Medications Patients diagnosed with… Read More

At the Premier Surgical Network, we are proud to offer both genetic testing and counseling services to our patients to support them throughout their breast health journey. Our team of surgeons are here to help you every step of the way when making informed decisions about your health. What is genetic testing? Genetic testing is done for individuals who have a genetic predisposition for developing breast cancer in the future, such as a family history. The BRCA gene test utilizes… Read More

Premier Surgical Network is proud to follow the American Cancer Society’s breast screening guidelines during COVID-19. While we understand that this can be a very difficult and overwhelming time for many, we would like to remind you that your breast health is a priority. Women at average risk for breast cancer should have annual screening breast mammography starting at age 45, and women ages 40-44 should also begin annual screening if they choose. During COVID-19, there has been an estimated… Read More

Breast Cancer Awareness month is celebrated each October. Breast Cancer is something that has impacted us deeply. As breast surgeons, this month means so much to us. We strive to provide compassionate care to our patients and their families as we navigate their treatment plan, surgery, and post-operative care. Breast Cancer Awareness Month allows us all to come together to support a common goal: The fight against Breast Cancer. This month, each of our surgeons answered a very important and… Read More